Altered salience network structure-function integration underlies the decline in cognitive flexibility during aging.

Abstract

Cognitive flexibility supports efficient switching between mental sets and contributes to the preservation of general cognition in aging. It relies on the integration between brain functional dynamics and structural architecture. However, how this structure-function integration changes with age and contributes to cognitive flexibility decline in older adults remains unclear. In this study, we investigated longitudinal aging-related changes in multimodal structure-function integration, quantified as functional signal alignment (i.e., coupling) versus liberality (i.e., decoupling) relative to individual structural connectomes, which represent distinct spectral components, and tested their longitudinal associations with cognitive flexibility. Resting-state fMRI signals were decomposed based on diffusion MRI-derived structural networks using a graph signal processing framework. We focused on subnetworks within three core large-scale cognitive systems: the executive control network (ECN), default mode network (DMN), and salience network (SN). Across two independent datasets, the task-positive SN-A subnetwork, which includes core SN regions such as the anterior insula and dorsal anterior cingulate cortex, exhibited decreased coupling and increased decoupling with aging. Importantly, these changes were associated with a greater decline in cognitive flexibility (measured by the Trail Making Test and Color Trails Test) over time. In contrast, task-negative DMN-A (centered in the medial prefrontal and posterior cingulate cortex) showed aging-related changes in the opposite direction, with increased coupling and decreased decoupling over time. Together, these findings reveal network-specific trajectories of intrinsic structure-function integration in normal aging and indicate that preserved structure-function integration within the SN may be particularly important for maintaining cognitive flexibility in older adults.