Aging and periodontitis increase brain dissemination of oral bacteria.

Ozge Unlu, Tsute Chen, Nil Yakar, Zeliha Guney, Bruce Paster, Isabel Carreras, Alpaslan Dedeoglu, Alpdogan Kantarci

The ADA Forsyth Institute, Cambridge, Massachusetts, USA.The ADA Forsyth Institute, Cambridge, Massachusetts, USA. · pubmed

Paper

Abstract

The microbiome is a dynamic system that changes throughout life. Studies have revealed the relationship between periodontal disease and the oral microbiota; however, the impact of periodontal disease on the expression of senescence markers and on the inflammaging of the oral and systemic microbiome remains unclear. We hypothesized that aging increases the periodontitis-induced changes in the oral and systemic microbiome and is accompanied by an altered inflammatory response.

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Research summary

The paper claims that aging exacerbates periodontitis-induced changes in the oral and systemic microbiome, leading to an altered inflammatory response. This research is relevant as it explores the interplay between aging and oral health, potentially linking periodontal disease to broader systemic aging processes.

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