Epigenetic transcriptional regulation of skeletal aging: The emerging role of m

Abstract

Bone plays critical roles in providing mechanical support, maintaining mineral homeostasis, and facilitating hematopoiesis. However, its structure and function progressively deteriorate with age. Although peak bone mass is achieved in early adulthood, aging is associated with decreased bone density, increased marrow adiposity, and accelerated bone turnover, collectively elevating the risk of fractures and osteoporosis (OP). With the growing elderly population worldwide, the socioeconomic burden of skeletal disorders-particularly OP-has intensified, highlighting the urgent need to elucidate their underlying molecular mechanisms for improved clinical management. Emerging evidence indicates that RNA modifications, especially N