Senescence Programs Shape the Chronic Wound Microenvironment.

Maria Shvedova, Minsung Cho, Jeroen Eyckmans, Daniel S Roh

Division of Plastic and Reconstructive Surgery, Department of Surgery, Boston University School of Medicine, Boston, Massachusetts, USA.Division of Plastic and Reconstructive Surgery, Department of Surgery, Boston University School of Medicine, Boston, Massachusetts, USA. · pubmed

Paper

Abstract

Chronic wounds such as diabetic foot ulcers, venous leg ulcers, and pressure ulcers are characterized by impaired healing and persistent inflammation. Cellular senescence, defined as irreversible growth arrest with a pro-inflammatory secretory phenotype (senescence-associated secretory phenotype), has emerged as a potential driver of these nonhealing states. While transient induction of senescence may aid acute repair, chronic accumulation of senescent cells is thought to disrupt tissue regeneration, promote extracellular matrix degradation, and sustain inflammation.

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Research summary

Chronic accumulation of senescent cells disrupts tissue regeneration and sustains inflammation in chronic wounds. This paper is relevant as it addresses cellular senescence, a key mechanism in aging that contributes to age-related diseases and impaired healing, potentially offering insights into interventions that could improve longevity and healthspan.

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