Ganoderic acid D alleviates vascular aging by restoring lysosomal function via stabilization of the VAPB-SNX25 tethering complex.

Haiying Zhang, Yu Chen, Zihan Zhong, Aiping Wang, Zhenmiao Qin, Shuyan Piao, Xu Huang, Min Zhang, Yan Liu, Jingwei Liang

Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education & Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, Hainan 571199, China.Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education & Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, Hainan 571199, China. · pubmed

Paper

Abstract

Vascular smooth muscle cell (VSMC) senescence is a major driver of age-related vascular remodeling and functional decline, and is closely associated with lysosomal dysfunction. However, there remains a lack of small molecules capable of precisely targeting lysosomes to improve vascular remodeling.

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Research summary

Ganoderic acid D restores lysosomal function and alleviates vascular aging by stabilizing the VAPB-SNX25 tethering complex. This research addresses a root cause of vascular aging, which is closely linked to overall aging processes and age-related diseases.

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