Chlorogenic acid ameliorates ovarian aging in laying chickens by restoring lipid metabolism and steroidogenesis via the ERK/PPARα signaling pathway.

Xiangyu Cai, Zhaoyu Yang, Yingyu Xiao, Qiongyu Yuan, Wanyue Gao, Jing Dong, Weidong Zeng, Yuling Mi, Caiqiao Zhang

Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China. · pubmed

Paper

Abstract

Ovarian aging is characterized by progressive impairments of follicular development and reproductive performance. Increasing evidence indicates that metabolic dysregulation plays a central role in the decline of ovarian function. Chlorogenic acid (CGA), a widely distributed plant-derived polyphenol, is known for its antioxidant, anti-inflammatory, and metabolic properties. However, its potential role in ovarian aging and the underlying mechanisms remain unexplored.

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Research summary

Chlorogenic acid improves ovarian aging by enhancing lipid metabolism and steroidogenesis through the ERK/PPARα signaling pathway. The study addresses metabolic dysregulation in ovarian aging, which is a significant aspect of reproductive aging and longevity.

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