Genome-wide association study and pathway analysis of healthy aging in Super Seniors.
Abstract
Healthy aging is a complex process influenced by genetic, environmental, and lifestyle factors. Although prior genetic studies have identified loci associated with longevity, replication has often been limited by strong non-genetic influences. To investigate the genetic contributors to healthy aging, we performed a genome-wide association study (GWAS) and pathway analyses in 597 Super Seniors-individuals aged ≥ 85 years with no history of cancer, cardiovascular disease, diabetes, dementia, or major pulmonary disease-compared to 420 mid-life population-based controls that represent the population before selection for survival from age-related disorders. Candidate variant analyses confirmed known associations at the APOE locus, where APOE4 carriers had reduced odds of healthy aging (P = 0.0025), with stronger effects in females (P = 8.82 × 10⁻
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Research summary
The paper identifies genetic variants associated with healthy aging in Super Seniors, suggesting that certain genetic factors may contribute to longevity. The study focuses on genetic contributors to healthy aging, which aligns with the investigation of the root causes of aging rather than merely addressing age-related diseases.
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