A targeted epigenetic clock for simultaneous assessment of biological aging and cancer-associated methylation drift.

Feng Liu, Haohao Li, Tianzhe Chen, Xiaoliang Chen, Bo Hong, Hongzhi Wang, Yeping Tu, Jinfu Nie

Zhongke Jinchen Biotechnology, Hefei, 230051, Anhui, China.Zhongke Jinchen Biotechnology, Hefei, 230051, Anhui, China. · pubmed

Paper

Abstract

As a key tool for assessing aging, DNA methylation clocks are mostly constructed based on European and American populations and rely on the high-cost Infinium MethylationEPIC microarray. These factors limit their widespread application in the Chinese population.

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Research summary

The paper proposes a targeted epigenetic clock that assesses biological aging and cancer-associated methylation drift. This research is relevant as it aims to improve the understanding of biological aging mechanisms and their relationship with cancer, potentially addressing root causes of aging.

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