Unraveling the complexity of skin's biological aging utilizing epigenetic clocks.

Agata Bienkowska, Minyue Qi, Konstantina Kanta, Maria Del Pilar Bonilla-Tobar, Henry Völzke, Stefan Gallinat, Sören Jaspers, Sven Clemann, Marc Winnefeld, Elke Grönniger, Lars Kaderali, Cassandra Falckenhayn

Research and Development, Beiersdorf AG, Hamburg, Germany. · pubmed

Paper

Abstract

DNA methylation (DNAm) plays a pivotal role in regulating gene expression and tissue function in the skin, which exhibits a high degree of responsiveness to environmental and lifestyle factors. These factors are believed to contribute to epigenetic drift, a hallmark of aging marked by increased methylation variability and changes in regulatory regions. While epigenetic clocks have advanced our understanding of skin aging, the effects of many modifiable factors on the skin methylome remain largely unknown.

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Research summary

The paper claims to explore the role of epigenetic clocks in understanding skin biological aging and the influence of modifiable factors on the skin methylome. This research is relevant as it addresses the underlying mechanisms of aging through epigenetic changes, which could lead to insights into longevity and age-related interventions.

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