Plasma acetic acid mediates the relationship between gut microbiome and various health measures in older adults.

Tiing Yee Siow, Alex Mun-Ching Wong, Ji-Tseng Fang, Cheng-Hsun Chiu, Yuan-Ming Yeh, Mei-Ling Cheng, Chi-Jen Lo, Shin-Nan Lin, Ching-Po Lin, Cheng Hong Toh

Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. · pubmed

Paper

Abstract

Short-chain fatty acids are believed to mediate microbiome-host interactions. Acetic acid is the most abundant systemic short-chain fatty acid, but knowledge about its physiological functions comes mainly from rodent experiments, with limited human research particularly in the aging population.

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Research summary

Plasma acetic acid mediates the relationship between gut microbiome and various health measures in older adults. This study explores the role of a short-chain fatty acid in the context of gut microbiome interactions, which may influence health outcomes in aging, thus addressing potential mechanisms related to longevity.

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