Genetic risk modifies the effect of exogenous nucleotides on insulin resistance in older adults: insights from multi-omics analyses.

Ruisheng Fu, Shuyue Wang, Yuxiao Wu, Xueying Qin, Tao Huang, Yong Li, Meihong Xu

Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China. [email protected]. · pubmed

Paper

Abstract

Nucleotides-fundamental cellular building blocks-are an underappreciated dietary component, especially in aging when metabolic resilience wanes. Whether genetic background determines who benefits from NTs has been unknown. Insulin resistance (IR) underlies age-related metabolic disorders, yet responses to nutritional interventions are heterogeneous. In this secondary analysis of the TALENTs randomized controlled trial (121 adults aged 60-70 years; 19-week intervention; NCT05243108), we tested whether genetic background-quantified by a fasting-glucose polygenic risk score (FBG-PRS)-modifies the effect of exogenous nucleotides (NTs) on IR. A significant PRS × intervention interaction was observed with changes in HOMA-IR (

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Research summary

The paper claims that genetic risk modifies the effect of exogenous nucleotides on insulin resistance in older adults. This research is relevant as it explores the interaction between genetic factors and dietary components in the context of insulin resistance, which is a significant aspect of metabolic health in aging populations.

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