Dietary ginsenosides for longevity: from biosynthesis and bioactive potential to functional food applications.

Chao Fang, Yujie Zhao, Haixia Yang, Daidi Fan, Jianjun Deng

Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, Biotech & Biomed Research Institute, School of Chemical Engineering, Northwest University, Xi'an, China.Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, Biotech & Biomed Research Institute, School of Chemical Engineering, Northwest University, Xi'an, China. · pubmed

Paper

Abstract

Ginsenosides, a class of bioactive substances, exhibit multi targets and notable anti-aging properties. However, their application as functional food ingredients is still limited. This review begins by examining the research advancements related to key drivers of aging, including mitochondrial dysfunction and oxidative stress. By integrating data from network pharmacology and molecular docking, it systematically reviews the intervention effects of ginsenosides on aging mechanisms that the regulation of cellular senescence and the maintenance of mitochondrial function and intestinal flora homeostasis. Biosynthesis strategies provide a viable pathway for the industrial production of ginsenosides and the development of functional foods. Furthermore, structural modifications combined with targeted delivery systems, supported by AI, have been strategically employed to enhance bioavailability and unlock their full bioactive potential as functional food ingredients. This work highlights the necessity of dietary ginsenosides in aging management based on the health burden of aging, and proposes an integrated strategy covering biosynthesis, mechanisms, AI-driven delivery applications and safety verification. It provides a comprehensive perspective on ginsenosides as functional food ingredients for evidence-based aging management.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that dietary ginsenosides can regulate aging mechanisms and enhance longevity through their bioactive properties. This research is relevant as it addresses potential interventions targeting the root causes of aging rather than merely treating age-related diseases.

Author of this paper? Send a correction.