Impact of acute blue light irradiation on the molecular clock and markers associated with photoaging in skin cell models.
Abstract
The increased reliance on digital devices in our daily lives has exposed humans to intense levels of high-energy blue light. However, the harmful effects of blue light irradiation on human skin are less understood than UV irradiation. Notably, we demonstrated that blue light induces skin photoaging through a novel mechanism involving disruption of the circadian rhythm. An in vitro study using human keratinocyte cells and dermal fibroblasts was conducted. The results showed that blue light irradiation triggers cellular senescence and downregulates key aging-associated markers, including extracellular matrix components, epithelial barrier protein, NAD
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Research summary
Blue light irradiation induces skin photoaging by disrupting the circadian rhythm and triggering cellular senescence. The study addresses a mechanism related to aging processes, specifically photoaging, which is relevant to understanding and potentially mitigating aspects of skin aging.
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