Anti-aging effects of low-molecular-weight polysaccharide PSP-1-1 from steamed Polygonatum sibiricum via gut microbiota modulation.

Chen Zhang, Hongru Lin, Congmin Wei, Xue Long, Shuomeng Bai, Haotian Wu, Xinran Li, Zhou Yang, Yihuai Gao, Hongbing Wang

Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200120, China. · pubmed

Paper

Abstract

The rising prevalence of aging-associated chronic conditions underscores the need for interventions that promote healthy aging. In this study, a low-molecular-weight polysaccharide (PSP-1-1, 2.7 kDa) was isolated from steamed Polygonatum sibiricum using bioactivity-guided purification and structurally characterized as a branched β-(1 → 4)-galactan with C-6 substitutions. Using Caenorhabditis elegans, PSP-1-1 demonstrated significant anti-aging effects and neuroprotective activities. Our results showed that PSP-1-1 (100 μg/mL) significantly delayed Aβ-induced paralysis of CL4176 worms, the value of PT

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Research summary

The paper claims that the low-molecular-weight polysaccharide PSP-1-1 from steamed Polygonatum sibiricum can delay aging-related paralysis in C. elegans. This research addresses potential interventions for aging by exploring the modulation of gut microbiota, which is relevant to the underlying mechanisms of aging and longevity.

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