An integrative single-nucleus multiomic atlas of the human left ventricle identifies gene regulatory network dynamics across cardiac development, aging, and disease.

William Gao, Peng Hu, Brittney Wick, Qi Qiu, Hongjie Zhang, Ying Li, Xiangjin Kang, Kenneth Bedi, Maximilian Haeussler, Kotaro Sasaki, Kenneth Margulies, Hao Wu

Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA. [email protected] of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA. [email protected]. · pubmed

Paper

Abstract

As the first organ to develop in utero, the human heart undergoes extensive molecular, structural and metabolic remodeling during development and must sustain its function throughout life.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper identifies gene regulatory network dynamics across cardiac development, aging, and disease. The focus on gene regulatory networks in the context of aging and cardiac function suggests potential insights into the mechanisms of aging and age-related diseases, which are relevant to longevity research.

Author of this paper? Send a correction.