Multi-omics and machine learning reveal a critical mediator of PRKCA in quercetin-mediated protection against Sarcopenia.

Xinjie Wu, Zhonghao Li, Xin Xu, Zhimu Yuan, Zhizhuo Li, Benlong Shi, Saihu Mao, Jun Qiao, Zhenhua Feng, Qingyu Zhang

Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China.Department of Orthopaedic Surgery, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China. · pubmed

Paper

Abstract

Sarcopenia, the age-associated loss of skeletal muscle mass and function, poses a growing public health challenge. Although dietary flavonoids have been proposed as protective agents due to their antioxidant and anti-inflammatory properties, their precise roles in sarcopenia prevention remain unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that PRKCA mediates the protective effects of quercetin against sarcopenia. The research addresses a significant aspect of aging by exploring potential interventions for sarcopenia, which is a critical age-related condition affecting muscle mass and function.

Author of this paper? Send a correction.