Exercise-induced irisin rescues lead-induced cognitive impairment by inhibiting prefrontal cortical senescence via SIRT3.

Hui Huang, Huiyuan Shi, Jian Sun, Xiaoming Song, Yuan Yu, Licheng Yan, Fan Shi, Weixuan Wang, Yanshu Zhang

School of Public Health, North China University of Science and Technology, Tangshan 063210, China; Hebei Key Laboratory of Occupational Health and Safety for Coal Industry, Tangshan 063210, China.School of Public Health, North China University of Science and Technology, Tangshan 063210, China; Hebei Key Laboratory of Occupational Health and Safety for Coal Industry, Tangshan 063210, China. · pubmed

Paper

Abstract

Lead (Pb) is a pervasive environmental hazard that impairs cognitive function. However, the underlying mechanisms and non-pharmacological interventions need to be further investigated. Here, Pb-induced senescence in the prefrontal cortex was associated with cognitive impairment. We found that exercise and exercise serum ameliorated Pb-induced prefrontal cortex senescence and cognitive impairment in mice. Further analyses revealed that exercise-derived irisin alleviated cellular senescence by regulating the SIRT3 signaling pathway. Meanwhile, irisin also mediated the association between blood Pb levels and MoCA scores in humans. Together, these findings suggest that exercise alleviates Pb-induced cognitive impairment via the irisin-SIRT3 pathway and identify irisin as a potential therapeutic target.

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Research summary

Exercise-derived irisin alleviates lead-induced cognitive impairment by regulating the SIRT3 signaling pathway. The paper addresses the impact of exercise on cellular senescence and cognitive function, linking it to potential mechanisms of aging and cognitive decline, which are relevant to longevity research.

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