Sex differences in response to longevity interventions.
Abstract
Interventions to extend lifespan and healthspan are of major interest, but such interventions may affect male and female organisms differently. Whether this is due sex-specific differences in baseline lifespan, or differences in sexually dimorphic characteristics such as body size, adiposity, metabolism, or even gonadal hormone or chromosome status remains unknown. Here we discuss the literature on how males and females respond differently to various types of interventions known to extend lifespan and explore possible underlying mechanisms. Ultimately, understanding sex as a biological variable in the context of aging may reveal sex-specific strategies to improve healthspan and treat age-related disease.
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper discusses how sex differences affect responses to longevity interventions. Understanding these differences is crucial for developing targeted strategies to extend lifespan and improve healthspan, which aligns with the core goals of longevity research.
Author of this paper? Send a correction.