Zuogui pill ameliorates DNA damage and the senescence-associated secretory phenotype in ovarian stem cells to delay ovarian ageing through activation of SIRT1.

Yi-Xuan Wang, Yun-Shuo Zhang, Xin Liu, Jun-Yi An, Guan-Ying Li, Yu-Xin Zou, Yun-Ling Zheng, Yuan Fang, Kai-Xuan Li, Ling Zhu

Guangzhou University of Chinese Medicine, Guangzhou 510407, China; The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510407, China; Lingnan Medical Research Center, Guangdong Provincial Clinical Research Academy of Chinese Medicine, Guangzhou 510407, China.Guangzhou University of Chinese Medicine, Guangzhou 510407, China; The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510407, China; Lingnan Medical Research Center, Guangdong Provincial Clinical Research Academy of Chinese Medicine, Guangzhou 510407, China. · pubmed

Paper

Abstract

Ovarian aging, which progresses faster than overall organismal aging, represents a major public health challenge, profoundly impacting female reproductive health and accelerating societal aging. The traditional Chinese medicine formula Zuogui Pill (ZGP) has shown great potential in delaying ovarian aging, warranting further investigation and development.

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Research summary

The paper claims that Zuogui Pill can ameliorate DNA damage and the senescence-associated secretory phenotype in ovarian stem cells to delay ovarian aging through activation of SIRT1. This research addresses the mechanisms of ovarian aging, which is a critical aspect of female reproductive health and overall aging, thus contributing to the understanding of longevity.

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