Blood neurodegeneration biomarkers and the muscle-brain axis in older adults: physical performance as a functional mediator of cognition.

Chiara Ceolin, Marianna Noale, Giulia Musso, Silvia Sturani, Adele Ravelli, Cristina Simonato, Luca Busetto, Angelo Antonini, Eleonora Fiorenzato, Martina Montagnana, Alessandra Coin, Maria Devita, Giuseppe Sergi, Marina De Rui

Department of Medicine (DIMED), University of Padua, Padua, Italy; Geriatric Unit, University Hospital of Padua, Padua, Italy; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Aging Research Center, Stockholm, Sweden. Electronic address: [email protected]. · pubmed

Paper

Abstract

Age-related neuromuscular decline may reflect the muscle-brain axis linking neurodegeneration to cognitive impairment. This study examines whether physical performance mediates associations between blood neurodegeneration biomarkers and cognition, and whether cognitive reserve modulates these relationships.

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Research summary

Physical performance mediates the relationship between blood neurodegeneration biomarkers and cognition in older adults. This study explores the connections between physical performance and cognitive function, which are critical aspects of aging and longevity research.

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