Discovery of frailty-linked proteins through multi-omics integration of brain and plasma proteomes with GWAS datasets.

JiaYu Zhong, MingHao Yuan, En Zhou, Shuo Hu

Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. · pubmed

Paper

Abstract

Frailty, a clinical state of increased vulnerability to stressors with aging, imposes significant strain on healthcare systems. Its genetic underpinnings remain incompletely explored, highlighting the need to identify novel therapeutic targets for aging.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper identifies frailty-linked proteins through multi-omics integration, suggesting potential therapeutic targets for aging-related vulnerabilities. The focus on frailty as a clinical state related to aging aligns with the exploration of underlying mechanisms of aging rather than merely addressing symptoms.

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