Reduced Frontal White Matter Hyperintensities in Superagers: Evidence of Resistance to Age-Related Structural Brain Changes.

Laiz Laura de Godoy, Carole H Sudre, Adalberto Studart-Neto, Bruno Pastorello, Natália Cristina Moraes, Mônica Sanches Yassuda, Ricardo Nitrini, Francesco Carletti, Claudia da Costa Leite, Sotirios Bisdas, Hans Rolf Jäger

From the Department of Radiology and Oncology (L.L.d.G., B.P., C.d.C.L.), Hospital das Clinicas, Faculty of Medicine of the University of São Paulo, Universidade de Sao Paulo, Sao Paulo, SP, Brazil [email protected] the Department of Radiology and Oncology (L.L.d.G., B.P., C.d.C.L.), Hospital das Clinicas, Faculty of Medicine of the University of São Paulo, Universidade de Sao Paulo, Sao Paulo, SP, Brazil [email protected]. · pubmed

Paper

Abstract

Superagers are older adults who maintain exceptional memory performance despite their age. This study aimed to investigate whether local differences in white matter hyperintensities (WMH) and microstructural integrity of normal-appearing white matter (NAWM) could help explain the superager phenotype.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that superagers exhibit reduced frontal white matter hyperintensities and better microstructural integrity in white matter compared to their peers. This research is relevant as it explores structural brain changes associated with exceptional cognitive aging, potentially contributing to understanding mechanisms that promote longevity and resilience against age-related decline.

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