Integrative Dermatology for Longevity: The Synergy of Topical and Internal Approaches.

Diala Haykal, Frederic Flament, Guive Balooch, Pascale Mora, Natalia Kovylkina, Livia Salomao Calixto, Daiane Garcia Mercurio, Mukta Sachdev, Hema Sundaram

Centre Laser Palaiseau, Private Practice, Palaiseau, France.Centre Laser Palaiseau, Private Practice, Palaiseau, France. · pubmed

Paper

Abstract

Skin aging reflects both intrinsic biological decline and extrinsic influences collectively known as the skin exposome, including ultraviolet (UV) radiation, air pollution, psychosocial stress, fatigue, sleep disruption, and suboptimal lifestyle behaviors. These factors contribute to cumulative molecular and structural damage, positioning the skin as both a visible marker of whole-body aging and a target for longevity strategies. This review examines the validity of an integrative "In and Out" approach, combining topical treatments, such as retinoids, peptides, antioxidants, and exosome-based formulations, with internal nutraceuticals including NAD

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Research summary

The paper claims that an integrative approach combining topical and internal treatments can effectively address skin aging and contribute to longevity. This paper is relevant as it explores strategies that target the biological mechanisms of aging through both external and internal interventions.

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