Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice.

Daniela G Costa, Lucy M Gee, Gung Lee, Lilian Sales Gomez, Ana Catarina Franco, Maria Grazia Vizioli, Karla Valdivieso, Lei J Zhang, Nick Pirius, Helene Martini, Rebecca A Porritt, Dominik Saul, Claudia Cavadas, Scott Ebert, Nathan K LeBrasseur, Sundeep Khosla, João F Passos, Christopher M Adams, Paul D Robbins, Diana Jurk

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA. · pubmed

Paper

Abstract

Cellular senescence drives aging and age-related dysfunction across multiple tissues, including the brain. Through a high-content, senescent cell-based phenotypic screen of a small panel of natural products, we identified tomatidine, an aglycone of tomatine found in tomatoes, as a previously unrecognized senotherapeutic agent. In senescent human brain microvascular endothelial cells and fibroblasts, tomatidine selectively suppressed SASP expression without affecting p16

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Research summary

Tomatidine is identified as a senotherapeutic agent that improves cognitive function and reduces cellular senescence in aged mice. This research addresses the root causes of aging by targeting cellular senescence, which is a significant contributor to age-related dysfunction.

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