Farnesoid X receptor deficiency accelerates aging and systemic functional decline in male mice.
Abstract
Aging is accompanied by progressive functional decline, and nuclear receptors have become significant modulators of the process. Farnesoid X receptor (FXR), a ligand activated nuclear receptor transcription factor that regulates genes involved in bile acid and metabolic homeostasis, has been implicated in aging, yet genetic evidence remains limited. In this study, we demonstrate that FXR knockout (FXR
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Research summary
The paper claims that the deficiency of Farnesoid X receptor accelerates aging and systemic functional decline in male mice. This research investigates a potential root cause of aging through the role of a nuclear receptor, which is relevant to understanding and potentially mitigating aging processes.
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