MYSM1 expression in monocytes is negatively correlated to disease activity in Rheumatoid Arthritis, which may be related to the inhibitory effect on inflammatory aging.

Rirong Huang, Shulv Quan, Jingyan Zeng, Jiayu Shi, Jialin Zhang, Ensheng Chen, Pan Liao, Xing Li

Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China. · pubmed

Paper

Abstract

Inflammatory aging is a key contributor to the onset and progression of rheumatoid arthritis (RA). The deubiquitinase Myb-like, SWIRM, and MPN domain-containing protein 1 (MYSM1) is known to play a crucial role in DNA damage repair and inflammatory aging, however, the precise mechanisms by which it exerts these effects remain unclear. This study aimed to investigate the relationship between MYSM1 expression in peripheral blood mononuclear cells (PBMCs) and DNA damage-induced inflammatory aging in RA patients, elucidating its potential role in RA pathogenesis.

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Research summary

MYSM1 expression in monocytes is negatively correlated to disease activity in Rheumatoid Arthritis, potentially influencing inflammatory aging. The study addresses the role of MYSM1 in inflammatory aging, which is a key factor in the pathogenesis of rheumatoid arthritis, linking it to broader implications for aging and age-related diseases.

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