Mitochondrial DNA as a driver of inflammation via the cGAS-STING pathway.

Xingyue Wen, Fan Yang, Lan Zhang, Dingming Huang

State Key Laboratory of Oral Diseases and National Center for Stomatology and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, Sichuan Province, China.State Key Laboratory of Oral Diseases and National Center for Stomatology and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, Sichuan Province, China. · pubmed

Paper

Abstract

Mitochondrial DNA (mtDNA), acting as a critical damage associated molecular pattern (DAMP), can translocate into the cytoplasm and directly activate the cGAS-STING signaling pathway. This activation induces the production of type I interferons and senescence associated secretory phenotype (SASP), positioning mtDNA as a key regulator of both inflammation and cellular senescence, namely mtDNA-cGAS-STING signaling axis.

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Research summary

Mitochondrial DNA activates the cGAS-STING pathway, leading to inflammation and cellular senescence. This research is relevant as it explores the role of mtDNA in inflammation and senescence, which are key processes in aging and age-related diseases.

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