Longevity factor klotho and resistance to cognitive deficits in individuals with Parkinson's disease and in an α-synuclein mouse model.

Nijee S Luthra, Luke W Bonham, Arturo J Moreno, Cana Park, Claire J C Huguenard, Samira Abdulai-Saiku, Shweta Gupta, Jonathan Lin, Lauren Broestl, Alexandre Bétourné, Rohan Sehgal, Dan Wang, Sylvain E Lesné, Jill L Ostrem, Jennifer S Yokoyama, Dena B Dubal

Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158; [email protected] [email protected] of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158; [email protected] [email protected]. · pubmed

Paper

Abstract

Aging is the primary risk factor for Parkinson's disease (PD) and PD-related cognitive impairment remains a major unmet biomedical challenge. Klotho, a pleiotropic protein, extends lifespan and enhances cognition, but whether it confers resilience to cognitive impairments in PD is unclear. Here, we show that in humans, the KL-VS genetic variant of

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Research summary

The paper investigates the role of the KL-VS genetic variant of klotho in providing resilience to cognitive impairments in Parkinson's disease. This research is relevant as it explores a potential mechanism related to aging and cognitive decline, which could contribute to understanding longevity and age-related diseases.

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