Endothelial decorin in cardiac ageing: mechanistic ambiguities and therapeutic challenges.

DuJiang Yang, GuoYou Wang

The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, NO.182, Chunhui Road, Longmatan District, Luzhou, Sichuan Province, 646000, P.R. China.The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, NO.182, Chunhui Road, Longmatan District, Luzhou, Sichuan Province, 646000, P.R. China. · pubmed

Paper

Abstract

This letter provides a critical analysis of the recent study by Luxán et al. (Cardiovasc Res. 2025) on the role of non-glycanated decorin in cardiac ageing. While acknowledging the importance of their findings, we identify several key areas requiring further investigation. These include: (1) the precise mechanistic origins of non-glycanated decorin accumulation in ageing endothelium; (2) the quantitative pathophysiological contribution of decorin-driven inflammation within the broader context of cardiac ageing; (3) the potential pleiotropic functions of decorin beyond inflammation; and (4) the significant translational challenges in targeting decorin-EGFR interactions. Resolving these issues is crucial for determining the therapeutic potential of modulating decorin in age-related cardiovascular pathologies.

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Research summary

The paper discusses the mechanistic origins and therapeutic challenges of non-glycanated decorin in cardiac ageing. The focus on understanding the underlying mechanisms of cardiac ageing and potential therapeutic interventions aligns with longevity research.

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