Ginsenoside Rb1 Ameliorates Age-Related Cognitive Impairment Potentially by Modulating the NF-κB Signaling Pathway.

Wei-Feng Lu, Yu-Zhen Zhang, Zhi-Gang Chen, Qun-Lin Xiao, Shi-Ye Ke

Department of Cardiology, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong Province, People's Republic of China.Department of Cardiology, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong Province, People's Republic of China. · pubmed

Paper

Abstract

Age-related cognitive impairment affects the quality of life of the elderly, contributing to a substantial healthcare burden. Ginsenoside Rb1 (Rb1), an active component of ginseng, has been shown to possess various biological functions, including antisenescence, anti-inflammatory, and neuroprotection effects. This study investigated whether Rb1 attenuates age-related cognitive impairment and aimed to elucidate the relevant molecular mechanism.

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Research summary

Ginsenoside Rb1 may improve age-related cognitive impairment by modulating the NF-κB signaling pathway. The paper is relevant as it explores a potential intervention that targets mechanisms associated with aging and cognitive decline, rather than merely addressing symptoms.

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