Determination of age-specific reference intervals for ethanolamine plasmalogen species in red blood cells using liquid chromatography tandem mass spectrometry.

Irene De Biase, Malgorzata Miller, Lauren M Zuromski, Katherine J Anderson, Stacey L Cole, Preejith P Vachali, Tatiana Yuzyuk

Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA; ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA. Electronic address: [email protected]. · pubmed

Paper

Abstract

Plasmalogens are essential membrane components predominantly generated by de novo synthesis beginning in peroxisomes. Hence, patients with peroxisome biogenesis defects exhibit markedly reduced plasmalogens. Moreover, a reduction in plasmalogens has been associated with several degenerative and metabolic disorders, as well as aging. Here, we characterized the distribution and changes over time of the most abundant ethanolamine plasmalogen (PlsEtn) species in packed red blood cells (RBCs) from healthy individuals, and established age-specific reference intervals (RIs).

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Research summary

The paper establishes age-specific reference intervals for ethanolamine plasmalogen species in red blood cells. The study is relevant as it investigates a biomarker associated with aging and metabolic disorders, contributing to the understanding of age-related changes in plasmalogen levels.

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