Oriented Immobilization Coupled With Ligand Fishing Strategy for Rapid Discovery of Direct HMGB1 Inhibitors in Taxus wallichiana var. mairei.
Abstract
High Mobility Group Box 1 (HMGB1), a non-histone chromatin protein, is a key inflammatory cytokine. Direct HMGB1 inhibitors have gained attention for their therapeutic potential in age-related diseases by blocking the pro-inflammatory activity of extracellular HMGB1, but remain limited. Here, an immobilized HMGB1 was synthesized in one step using an oriented immobilization approach and applied to efficiently acquire direct HMGB1 inhibitors from a highly complex matrix. The oriented immobilization method employed a Ni
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Research summary
The paper claims to develop a method for discovering direct HMGB1 inhibitors that could potentially block pro-inflammatory activity associated with age-related diseases. The research addresses a mechanism related to inflammation, which is a contributing factor to aging and age-related diseases, thus making it relevant to longevity research.
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