NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K

Nancy C Allen, Christian Ringler, Sang Ho Woo, Sophie Phipps, Jin Young Lee, Nabora Reyes, Ritusree Biswas, Lucile Neyton, Andrew Willmore, Sofia Caryotakis, Jessica Roginsky, Lu Guo, Melia Magnen, Pedro Ruivo, Chaz Langelier, Mark Looney, Averil Ma, Vincent Auyeung, Carolyn Calfee, Ari B Molofsky, Tien Peng

Department of Medicine, San Francisco, CA, USA; Bakar Aging Research Institute, San Francisco, CA, USA.Department of Medicine, San Francisco, CA, USA; Bakar Aging Research Institute, San Francisco, CA, USA. · pubmed

Paper

Abstract

While inflammaging supposedly drives some of the most common diseases affecting the elderly, little is known about the tissue drivers of inflammaging. In this study, we demonstrate that age-dependent activation of nuclear factor κB (NF-κB) in tissue fibroblasts remodeled the immune architecture, promoting the emergence of an exhausted granzyme K (GZMK)

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Research summary

The paper claims that age-dependent activation of NF-κB in fibroblasts drives the remodeling of immune architecture and promotes pro-inflammatory granzyme K. This research addresses the underlying mechanisms of inflammaging, which is a significant factor in age-related diseases, thus contributing to the understanding of aging processes.

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