MicroRNA-128-3p Deficiency Alleviates Bone Loss in Age-Related Osteoporosis via Activation of Canonical Wnt Signaling.

Gengyang Shen, Kun Chen, Qi Shang, Honglin Chen, Yu Liu, Guifeng Chen, Weicheng Qin, Jiahui He, Yuzhuo Zhang, Wenhua Zhao, Weiyu Qiu, Jingzhi Zhang, Hui Ren, Xiaobing Jiang

The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. · pubmed

Paper

Abstract

MicroRNA-128-3p (miR-128-3p) has emerged as a crucial regulator of the aging process and age-associated disorders. Recent research highlights the vital role of miR-128-3p in osteoclast (OC) differentiation and the progression of osteoporosis following ovariectomy. Nonetheless, the mechanism by which miR-128-3p influences osteoblast (OB)-mediated bone formation and contributes to bone loss associated with aging is poorly understood. The present investigation began with an analysis of human bone samples, in which we observed that the age-related miR-128-3p increase was negatively correlated with bone formation. In addition, miR-128-3p expression decreased during OB differentiation. Next, we found that OB miR-128-3p conditional deletion (cKO, miR-128-3p

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Research summary

The paper claims that deficiency of miR-128-3p alleviates bone loss in age-related osteoporosis through the activation of canonical Wnt signaling. This research is relevant as it explores a potential mechanism underlying bone loss associated with aging, addressing a root cause of age-related osteoporosis rather than merely treating symptoms.

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