Age-related decline of platelet-derived growth factor receptor alpha in mesenchyme surrounding meibomian gland leads to meibomian gland dysfunction.

Ke Xiong, Peiyao Lin, Zihan Wang, Ruimin Wu, Tangqin Mai, Shangzhang Tang, Yue Chen, Yuying Xiao, Min Fu, Wanjing Huang, Guijun Wu, Qing Tan, Siyuan Zhu, Yaru Su

Department of Ophthalmology, Nanfang Hospital, Southern Medical University, Guangzhou, China.Department of Ophthalmology, Nanfang Hospital, Southern Medical University, Guangzhou, China. · pubmed

Paper

Abstract

The meibomian glands (MGs) in the eyelids produce oil to prevent tear evaporation, a function that declines with age. The mechanisms underlying MGs homeostasis and the pathogenesis leading to age-related meibomian gland dysfunction (ARMGD) remain largely unexplored. MGs contain secretory acini enveloped by a substantial mesenchyme. Previous studies have identified that ARMGD resulted from the failure to replenish acinar cells due to their senescence. Few studies, however, explored the role of age-related changes in mesenchyme contributing to ARMGD. Here, we demonstrated that an age-dependent decline in platelet-derived growth factor receptor alpha (PDGFR-α) within the peri-glandular mesenchyme was associated with ARMGD progression in both mice and humans. Furthermore, we discovered PDGFR-α

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Research summary

The paper claims that an age-dependent decline in PDGFR-α in the mesenchyme surrounding meibomian glands contributes to age-related meibomian gland dysfunction. This research explores the underlying mechanisms of aging-related dysfunction, which is relevant to understanding the biological processes of aging.

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