Effect of caloric restriction on organ-specific biological aging in a randomized clinical trial.

Yucan Li, Xinming Xu, Raghav Sehgal, Xinyi He, Yi Zheng, Xingdong Chen, Kelin Xu

State Key Laboratory of Genetics and Development of Complex Phenotypes, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, 201203, China; Department of Biostatistics, School of Public Health, The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, 200032, China. · pubmed

Paper

Abstract

Caloric restriction (CR) has demonstrated benefits in improving individual biomarkers and longevity, but its organ-specific systemic effects remain unclear. We aimed to quantify the effects of long-term CR on longitudinal changes in organ-specific biological age across multiple physiological systems.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that long-term caloric restriction can lead to measurable changes in organ-specific biological age. This research is relevant as it investigates a potential intervention (caloric restriction) that may address the biological mechanisms of aging, rather than merely treating age-related diseases.

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