Mitochondrial Dysfunction in Renal Aging: A Vicious Cycle Driving Kidney Disease Progression.
Abstract
The aging of the global population is linked to an increase in age-related diseases. The kidneys undergo both structural and functional declines with age, and aging is a significant risk factor for kidney diseases. Mitochondrial dysfunction is recognized as a crucial factor affecting kidney aging. Although the importance of disrupted mitochondrial homeostasis in renal aging has gained increasing attention, the associations and causal mechanisms have not been systematically summarized.
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Research summary
Mitochondrial dysfunction contributes to kidney aging and disease progression. The paper addresses a fundamental aspect of aging by exploring mitochondrial dysfunction as a root cause of renal aging, which is relevant to longevity research.
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