Dasatinib and quercetin prevent alveolar bone loss in aged mice.

Luisa S Battistelli, Renata M Moraes, Yuri C Santos, Jaqueline L Ribeiro, Maíra T Garcia, Renata F Prado, Florent Elefteriou, Ana Lia Anbinder

Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São José dos Campos, São Paulo State University (UNESP), São José dos Campos, SP, Brazil. · pubmed

Paper

Abstract

Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro-inflammatory environment which may exacerbate tissue damage. Senolytics, such as dasatinib and quercetin (D&Q), eliminate senescent cells, offering potential therapeutic benefits. We evaluated the effects of D&Q on ABL during physiological aging and experimental periodontitis.

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Research summary

Dasatinib and quercetin prevent alveolar bone loss in aged mice by eliminating senescent cells. This research addresses the root cause of aging by targeting senescent cells, which are implicated in age-related tissue degeneration.

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