Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in
Abstract
Aging is characterized by a decline in essential sensory functions, including olfaction, which is crucial for environmental interaction and survival. This decline is often paralleled by the cellular accumulation of dysfunctional mitochondria, particularly detrimental in post-mitotic cells such as neurons. Mitochondrial stress triggers the mitochondrial unfolded protein response (UPR
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper claims that age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR, leading to degeneration of olfactory neurons and loss of olfactory function. This research addresses a mechanism related to aging and its effects on sensory function, which is relevant to understanding the biological processes underlying aging.
Author of this paper? Send a correction.