Exploring the causal link between long-term elevated plasma caffeine levels and age-related eye diseases using Mendelian randomization.

Hao Dong, Qiang Ding, Mei Liu

Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei Province, China. · pubmed

Paper

Abstract

Experimental evidence suggests that caffeine has the potential to reduce the risk of age-related eye diseases (AREDs). However, there is a lack of population-based evidence directly assessing whether long-term caffeine exposure benefits these conditions. In this study, we employ Mendelian randomization (MR) to evaluate the causal effects of long-term elevated plasma caffeine levels (PCL) on AREDs, including age-related macular degeneration (AMD), age-related cataract (ARC), and glaucoma.

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Research summary

The paper claims that long-term elevated plasma caffeine levels may causally reduce the risk of age-related eye diseases. This research is relevant as it explores a potential intervention that could influence the progression of age-related conditions, aligning with the broader goals of longevity research.

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