Bone marrow mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration by regulating HMGB1 acetylation via SIRT6.

Hongshen Wang, Yong Wen, Laoqi Mai, Xinyi Li, Yongpeng Lin, Zhifeng Xiao, Yongjin Li, Yuyi Zhang, Bolai Chen

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510120, China; Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, 510120, China; The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510120, China; Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, Guangdong, 510120, China; Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. · pubmed

Paper

Abstract

Intervertebral disc degeneration (IVDD) is a leading cause of low back and leg pain and is primarily driven by inflammation-induced apoptosis of nucleus pulposus (NP) cells. Bone marrow mesenchymal stem cell-derived exosomes (BMSC-exos) have shown strong therapeutic potential for degenerative diseases. Sirtuin 6 (SIRT6), a key regulator of aging and inflammation, has been closely associated with IVDD progression. Therefore, we hypothesized that BMSC-exos might alleviate IVDD by promoting SIRT6-mediated deacetylation of high mobility group box 1 (HMGB1), thereby suppressing inflammation.

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Research summary

Bone marrow mesenchymal stem cell-derived exosomes can alleviate intervertebral disc degeneration by promoting SIRT6-mediated deacetylation of HMGB1. The paper addresses a mechanism related to inflammation and aging, linking stem cell therapy to potential interventions in age-related degeneration.

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