Adipose Dicer-1 modulates systemic insulin signaling and longevity via a miR-8-Aop-Dilp6 axis.

María C Ingaramo, Francisco Ramello, Silvano J Santander, Yemina Abelendo, Andrés Dekanty

Instituto de Agrobiotecnología del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas, Santa Fe 3000, Argentina.Instituto de Agrobiotecnología del Litoral, Consejo Nacional de Investigaciones Científicas y Técnicas, Santa Fe 3000, Argentina. · pubmed

Paper

Abstract

Interorgan communication is essential for metabolic homeostasis and healthy aging, with adipose tissue acting as a central hub that coordinates systemic metabolism, stress responses, and longevity. Here, we show that the miRNA-processing enzyme Dicer-1 (Dcr-1) acts in the fat body (FB) to regulate Dilp2 secretion from brain insulin-producing cells (IPCs), thereby modulating systemic insulin signaling and lifespan in

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Research summary

The paper claims that Dicer-1 in adipose tissue regulates insulin signaling and lifespan through a specific miRNA pathway. This research addresses mechanisms of interorgan communication and metabolic regulation that are central to understanding aging and longevity.

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