Caloric restriction attenuates age-related liver and kidney alterations in mice: Histological evidence.

Carlos R Montes-de-Oca-Saucedo, Sheila A Villa-Cedillo, Cristina S Ríos-Vázquez, Eduardo A Álvarez-Tostado-Ojeda, Mario Murguía-Pérez, Eduardo Agustín-Godínez, Ricardo Ruiz-Salazar, Adolfo Soto-Domínguez, Odila Saucedo-Cárdenas

Department of Histology, Faculty of Medicine, Autonomous University of Nuevo Leon, Monterrey, Nuevo Leon, Mexico.Department of Histology, Faculty of Medicine, Autonomous University of Nuevo Leon, Monterrey, Nuevo Leon, Mexico. · pubmed

Paper

Abstract

This study evaluated the histological impact of long-term caloric restriction (CR) on liver and kidney aging, assessing fibrosis, metabolic overload, and senescence-associated readouts.

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Research summary

Caloric restriction mitigates age-related changes in liver and kidney tissues in mice. This study is relevant as it explores a potential intervention (caloric restriction) that addresses the biological mechanisms of aging rather than merely treating age-related diseases.

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