Gorab deficiency in skin dermis accelerates aging and is associated with dysregulation of RCHY1-mediated P53 ubiquitination.

Yanhong Li, Wei Liang, Yanfeng Xu, Yunlin Han, Wenjie Zhao, Siyuan Wang, Wei Deng, Chuan Qin

NHC Key Laboratory of Comparative Medicine, National Human Diseases Animal Model Resource Center, National Center of Technology Innovation for Animal Model; Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. · pubmed

Paper

Abstract

Mutations in and functional inactivation of the Gorab gene cause gerodermia osteodysplastica (GO), a disease featuring wrinkled skin and osteoporosis, but the underlying mechanisms of skin aging remain incompletely understood.

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Research summary

Gorab deficiency in skin dermis accelerates aging through dysregulation of RCHY1-mediated P53 ubiquitination. The study addresses a genetic factor that may contribute to the mechanisms of skin aging, which is relevant to understanding the biological processes underlying aging and potential interventions.

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