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RESEARCH PAPER / 2026-03-22

Metabolic flexibility following resistance exercise and a high protein diet in older men: results from a 12-week randomized controlled trial.

Corbin Griffen, Derek Renshaw, Michael Duncan, Alexander Dallaway, Harpal Randeva, Martin O Weickert, John Hattersley

Centre for Health and Life Sciences, Centre for Physical Activity, Sport and Exercise Sciences, Coventry University, Coventry, United Kingdom; Human Metabolism Research Unit, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom. Electronic address: [email protected] for Health and Life Sciences, Centre for Physical Activity, Sport and Exercise Sciences, Coventry University, Coventry, United Kingdom; Human Metabolism Research Unit, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom. Electronic address: [email protected]. · pubmed

Abstract

Aging and sarcopenia are associated with metabolic inflexibility. This study investigated the effects of resistance exercise (RE) and a high protein diet (PRO) on metabolic flexibility (the ability to adjust rates of substrate oxidation to changes in fuel availability) in older men.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that resistance exercise and a high protein diet improve metabolic flexibility in older men. This research addresses metabolic inflexibility, which is a significant aspect of aging and sarcopenia, thus contributing to our understanding of interventions that may enhance longevity and overall health in older populations.

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