Mediterranean diet preserves renal mitochondrial homeostasis and attenuates early diabetic kidney injury in db/db mice.

Giovanna Mercurio, Antonia Giacco, Nicla Scopigno, Michela Vigliotti, Vittorio Maria Mandrone, Matteo Mazzola, Ettore Varricchio, Alberto Fiore, Giuseppe Riccio, Maria Moreno, Federica Cioffi, Elena Silvestri

Department of Science and Technology, University of Sannio, Benevento, Italy.Department of Science and Technology, University of Sannio, Benevento, Italy. · pubmed

Paper

Abstract

Chronic hyperglycemia, oxidative stress, and mitochondrial dysfunction are central drivers of renal structural and functional alterations associated with metabolic disease and accelerated tissue aging. In type 2 diabetes mellitus (T2DM), these mechanisms contribute to early kidney injury and progressive decline in renal resilience. Dietary interventions, including the Mediterranean diet (MD), have been proposed as complementary strategies to counteract metabolic stress, yet mechanistic evidence at the renal mitochondrial level remains limited.

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Research summary

The paper claims that the Mediterranean diet can preserve renal mitochondrial homeostasis and reduce early diabetic kidney injury. This research is relevant as it explores dietary interventions that may address underlying mechanisms of metabolic stress and mitochondrial dysfunction, which are associated with aging and age-related diseases.

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