Modeling and evaluating longitudinal brain maintenance and cognitive reserve using episodic memory, brain structure, and functional connectivity in older adults.

Rachel M Morse, Lídia Vaqué-Alcázar, María Cabello-Toscano, Cristina Solé-Padullés, Lídia Mulet-Pons, Juan Pablo Martin Trias, Micael Andersson, Dídac Vidal-Piñeiro, Alvaro Pascual-Leone, Kristine Walhovd, Lars Nyberg, David Bartres-Faz

Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain. · pubmed

Paper

Abstract

Cognitive reserve (CR) and brain maintenance (BM) reflect better than expected cognition despite brain pathology and minimal age-related brain changes that explain stable cognition, respectively. Despite being commonly used, joint quantification of these concepts has been limited; our aim is to derive longitudinal CR and BM measures and investigate CR's relationship with education and functional connectivity. We analyzed longitudinal data from 451 participants (241 female, age

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Research summary

The paper aims to derive longitudinal measures of cognitive reserve and brain maintenance and their relationship with education and functional connectivity in older adults. This research is relevant as it explores cognitive resilience mechanisms that could contribute to healthier aging and longevity.

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