Oral microbiome and Frailty: Insights from NHANES 2009-2012 and Mendelian Randomization Analysis.

Ting Xu, Xichenhui Qiu, Qiqi Hang, Xiang Qi, Haokun Mei, Jiajie Guo, Yaguang Zheng, Minghui Ji, Qin Xu, Bei Wu

School of Nursing, Nanjing Medical University, Nanjing, China.School of Nursing, Nanjing Medical University, Nanjing, China. · pubmed

Paper

Abstract

Frailty is associated with increased risks of disability, hospitalization, and mortality. Emerging evidence suggests that the oral microbiome may influence frailty development, but population-based evidence is limited and causal relationships remain unclear. This study explored the link between oral bacteria and frailty, using genetic analysis to investigate causality.

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Research summary

The paper investigates the relationship between the oral microbiome and frailty, suggesting that oral bacteria may influence frailty development. This research is relevant as it explores potential underlying mechanisms that could contribute to aging and frailty, which are critical factors in longevity studies.

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