Reduced circulating progenitor cells in older adults with major depression: Evidence of accelerated biological aging.

Erica L Vieira, Perla El-Ahmad, Yuliya Nikolova, Tarek Rajji, Breno S Diniz

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada. · pubmed

Paper

Abstract

Major depression (or late-life depression [LLD]) is a prevalent and debilitating condition among older adults and is increasingly recognized as a contributor to accelerated biological aging. LLD has been associated with aging-related phenotypes, namely chronic inflammation and cellular senescence. However, stem and progenitor cell exhaustion, another pivotal hallmark of biological aging, remains understudied in this context. In this study, we investigated the absolute count and frequency of circulating progenitor cell populations in peripheral blood mononuclear cells (PBMC) of 38 older adults (LLD, n = 19; control, n = 19). CD34

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Research summary

The paper claims that older adults with major depression exhibit reduced circulating progenitor cells, suggesting a link between depression and accelerated biological aging. This study is relevant as it explores a potential biological mechanism underlying aging processes, specifically focusing on stem and progenitor cell exhaustion in the context of major depression, which may contribute to our understanding of aging and age-related diseases.

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