DNA Origami Nanotechnology in Aging-Related Degenerative Diseases: Current Advances and Future Directions.

Wei Luo, Xin Chen, Xiao Xiao, Jingdong Li, Linbo Gao

Laboratory of Molecular Translational Medicine, Center for Translational Medicine; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education; NHC Key Laboratory of Chronobiology (Sichuan University); Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.Laboratory of Molecular Translational Medicine, Center for Translational Medicine; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education; NHC Key Laboratory of Chronobiology (Sichuan University); Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China. · pubmed

Paper

Abstract

Aging-related degenerative diseases, particularly neurodegenerative, musculoskeletal, and cardiovascular disorders, represent a major global health challenge. Characterized by progressive and irreversible cellular and tissue deterioration, these conditions contribute substantially to disability, loss of function, and mortality in older populations. Despite advances in symptom management, early diagnosis and effective therapies remain limited, largely due to complex and multifactorial pathogenesis. DNA origami, an emerging nanotechnology, offers unique advantages such as nanoscale precision, structural programmability, biodegradability, and low toxicity, making it a promising platform for biomedical applications. Recent progress has highlighted its utility in biosensing, bioimaging, molecular detection, targeted drug delivery, immune modulation, and receptor recognition in models of aging-related degenerative diseases. Here, we summarize current advances in DNA origami-based biomedical applications for aging-related degenerative disorders and discuss key challenges including

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Research summary

The paper discusses the application of DNA origami nanotechnology in addressing aging-related degenerative diseases. This research is relevant as it explores innovative approaches that could potentially target underlying mechanisms of aging and improve therapeutic strategies.

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